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guaA [2017-8-11 16:0:3]
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guaA [2017-8-11 16:0:3]

GMP synthetase (glutamine-hydrolysing)
locus
BSU06360
pI
4.75
mw
57.78 kDa
protein length
513 aa Sequence Blast
gene length
1539 bp Sequence Blast
function
biosynthesis of GMP
product
GMP synthetase (glutamine-hydrolysing)
essential
no
ec
6.3.5.2
synonyms
guaB
Outlinks
KEGGBsubCycSubtiListUniProtExpression Browser

Genomic Context

      

categories

  • [category|SW 2|Metabolism] → [category|SW 2.5|Nucleotide metabolism] → [category|SW 2.5.2|Biosynthesis/ acquisition of nucleotides] → [category|SW 2.5.2.1|Biosynthesis/ acquisition of purine nucleotides]

    • Gene

    Coordinates
    692,740 → 694,281

    The protein

    Catalyzed reaction/ biological activity

  • ATP xanthosine 5'-phosphate L-glutamine H2O = AMP diphosphate GMP L-glutamate (according to Swiss-Prot)

    • Effectors of protein activity

  • the enzyme is inhibited by guanosine tetraphosphate ([SW|stringent response]) [Pubmed|409404]

    • Structure

  • [PDB|2YWB] (from ''Thermus thermophilus hb8'', 45% identity, 57% similarity)

    • additional information

  • belongs to the 100 [SW|most abundant proteins] [PubMed|15378759]

    • Expression and Regulation

    Operons

    genes
    [gene|AC67305E4C165CC1D785E49B7CD8335346134376|guaA]
    description
    [Pubmed|1312531]

    sigma factors

  • [protein|360F48D576DE950DF79C1A2677B7A35A8D8CC30C|SigA]: sigma factor, [Pubmed|1312531], in [regulon|360F48D576DE950DF79C1A2677B7A35A8D8CC30C|SigA regulon]
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    Biological materials

    Mutant

  • MGNA-A918 (yebB::erm), available at the [https://shigen.nig.ac.jp/bsub/resource/strainGeneDisrupted/detail/918 NBRP B. subtilis, Japan]

    • References

    Reviews

  • 11395405

    • Original publications

  • 1722815,1312531,409404,15378759,24682323,27120414